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Nik-related kinase regulates trophoblast proliferation and placental development by modulating AKT phosphorylation

2 Feb 2017

Abstract excerpt

Nik-related kinase (Nrk) is a Ser/Thr kinase and was initially discovered as a molecule that was predominantly detected in skeletal muscles during development. A recent study using Nrk-null mice suggested the importance of Nrk in proper placental development; however, the molecular mechanism remains unknown. In this study, we demonstrated that differentiated trophoblasts from murine embryonic stem cells (ESCs)...

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PMID: 28152035
DOI: 10.1371/journal.pone.0171503

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