Article
Nrk, an X-linked protein kinase in the germinal center kinase family, is required for placental development and fetoplacental induction of labor.
The Journal of biological chemistry - 19 Aug 2011
Denda Kimitoshi, Nakao-Wakabayashi Kanako, Okamoto Naoki, Kitamura Naomi, Ryu Je-Young, Tagawa Yoh-Ichi, Ichisaka Tomoko, Yamanaka Shinya, Komada Masayuki
Abstract excerpt
The complete mechanism of labor induction in eutherian mammals remains unclear. Although important roles for the fetus and placenta in triggering labor have been proposed, no gene has been shown to be required in the fetus/placenta for labor induction. Here we show that Nrk, an X-linked gene encoding a Ser/Thr kinase of the germinal center kinase family, is essential in the fetus/placenta for labor in mice. Nrk...
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