Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DNA replication stress: a source of APOBEC3B expression in breast cancer.

Genome biology - 30 Sept 2016

Cescon David W, Haibe-Kains Benjamin

Abstract excerpt

APOBEC cytidine deaminases have been implicated as major contributors to the mutation burden in many cancers on the basis of their mutational signature. A new experimental study sheds light on the inciting factors, linking APOBEC3B expression to oncogene- and drug-induced replication stress.

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytidine Deaminase
Share to DNA Replication
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome, Human

Share to Genomics

Share to Minor Histocompatibility Antigens

Share to Multigene Family

Share to Stress, Physiological

Source

Open in PubMed Open full text

Identifiers

PMID: 27716362
DOI: 10.1186/s13059-016-1069-y
PMCID: PMC5045630

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DNA replication stress: a source of APOBEC3B expression in breast cancer.PMID 27716362Read ↗

DNA replication stress mediates APOBEC3 family mutagenesis in breast cancer.Semantic proximity Read ↗

APOBEC3B is an enzymatic source of mutation in breast cancer.Semantic proximity Read ↗

APOBEC in breast cancer: a dual player in tumor evolution and therapeutic responseSemantic proximity Read ↗

APOBEC3 cytidine deaminases in double-strand DNA break repair and cancer promotion.Semantic proximity Read ↗

APOBEC3A is a prominent cytidine deaminase in breast cancer.Semantic proximity Read ↗

Molecular mechanism and clinical impact of APOBEC3B-catalyzed mutagenesis in breast cancer.Semantic proximity Read ↗

Exploiting DNA Replication Stress as a Therapeutic Strategy for Breast CancerSemantic proximity Read ↗

DNA replication stress as a hallmark of cancer.Semantic proximity Read ↗

The interesting relationship between APOBEC3 deoxycytidine deaminases and cancer: a long road ahead.Semantic proximity Read ↗

<i>APOBEC3B</i> expression in breast cancer reflects cellular proliferation, while a deletion polymorphism is associated with immune activationSemantic proximity Read ↗

Characterization of the mechanism by which the RB/E2F pathway controls expression of the cancer genomic DNA deaminase APOBEC3BSemantic proximity Read ↗

Evidence for APOBEC3B mutagenesis in multiple human cancers.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.