Article
Characterization of CD44+ALDH1+Ki-67- Cells in Non-malignant and Neoplastic Lesions of the Breast.
Anticancer research - 1 Sept 2016
DA Cruz Paula Arnaud, Marques Oriana, Sampaio Rita, Rosa Ana, Garcia José, Rêma Alexandra, DE Fátima Faria Maria, Silva Paula, Vizcaíno Ramón, Lopes Carlos
Abstract excerpt
BACKGROUND: Cancer stem cells are tumor cells that present self-renewal, clonal tumor initiation capacity and clonal long-term repopulation potential. We have previously demonstrated that the co-expression of the breast cancer stem cell (BCSC) markers hyaluronan receptor (CD44) and aldehyde dehydrogenase-1 (ALDH1) in ductal carcinomas in situ could be determinant for disease progression. Combining these...
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