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Article

ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome.

Cell stem cell - 1 Nov 2007

Ginestier Christophe, Hur Min Hee, Charafe-Jauffret Emmanuelle, Monville Florence, Dutcher Julie, Brown Marty, Jacquemier Jocelyne, Viens Patrice, Kleer Celina G, Liu Suling, Schott Anne, Hayes Dan, Birnbaum Daniel, Wicha Max S, Dontu Gabriela

Abstract excerpt

Application of stem cell biology to breast cancer research has been limited by the lack of simple methods for identification and isolation of normal and malignant stem cells. Utilizing in vitro and in vivo experimental systems, we show that normal and cancer human mammary epithelial cells with increased aldehyde dehydrogenase activity (ALDH) have stem/progenitor properties. These cells contain the subpopulation...

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Identifiers

PMID: 18371393
DOI: 10.1016/j.stem.2007.08.014
PMCID: PMC2423808

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome.PMID 18371393Read ↗

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