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Novel molecular regulators of breast cancer stem cell plasticity and heterogeneity

18 Mar 2021

Abstract excerpt

Tumors consist of heterogeneous cell populations, and tumor heterogeneity plays key roles in regulating tumorigenesis, metastasis, recurrence and resistance to anti-tumor therapies. More and more studies suggest that cancer stem cells (CSCs) promote tumorigenesis, metastasis, recurrence and drug resistance as well as are the major source for heterogeneity of cancer cells. CD24−CD44+ and ALDH+ are the most common...

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PMID: 33737107
DOI: 10.1016/j.semcancer.2021.03.008

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