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Article

Heterogeneity of Human Breast Stem and Progenitor Cells as Revealed by Transcriptional Profiling.

Stem cell reports - 8 May 2018

Colacino Justin A, Azizi Ebrahim, Brooks Michael D, Harouaka Ramdane, Fouladdel Shamileh, McDermott Sean P, Lee Michael, Hill David, Madden Julie, Boerner Julie, Cote Michele L, Sartor Maureen A, Rozek Laura S, Wicha Max S

Abstract excerpt

During development, the mammary gland undergoes extensive remodeling driven by stem cells. Breast cancers are also hierarchically organized and driven by cancer stem cells characterized by CD44+CD24low/- or aldehyde dehydrogenase (ALDH) expression. These markers identify mesenchymal and epithelial populations both capable of tumor initiation. Less is known about these populations in non-cancerous mammary glands....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29606612
DOI: 10.1016/j.stemcr.2018.03.001
PMCID: PMC5995162

Genes

SOX2
TWIST1
ZEB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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