Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

High expression of stem cell marker ALDH1 is associated with reduced BRCA1 in invasive breast carcinomas.

Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2012

Madjd Zahra, Ramezani Babak, Molanae Saadat, Asadi-Lari Mohsen

Abstract excerpt

BACKGROUND: Cancer stem cells (CSC) have been described in a variety of malignancies, including breast carcinomas. Among several markers, aldehyde dehydrogenase 1 (ALDH1) has been identified as reliable for breast cancer stem cells. Knockdown of BRCA1 in primary breast epithelial cells leads to an increase in cells expressing ALDH1. METHODS: We examined 127 breast carcinomas for expression of ALDH1, using...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aldehyde Dehydrogenase 1 Family
Share to BRCA1 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease-Free Survival

Share to Isoenzymes

Share to Lymphatic Metastasis

Share to Neoplasm Invasiveness

Share to Neoplastic Stem Cells

Share to Retinal Dehydrogenase

Source

Identifiers

PMID: 22938492
DOI: 10.7314/apjcp.2012.13.6.2973

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

High expression of stem cell marker ALDH1 is associated with reduced BRCA1 in invasive breast carcinomas.PMID 22938492Read ↗

Expression of the stem cell marker ALDH1 in BRCA1 related breast cancerSemantic proximity Read ↗

ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome.Semantic proximity Read ↗

Stem Cell Marker Aldehyde Dehydrogenase 1 (ALDH1)-Expressing Cells are Enriched in Triple-Negative Breast CancerSemantic proximity Read ↗

Breast cancer stem cells expressing different stem cell markers exhibit distinct biological characteristics.Semantic proximity Read ↗

Cancer stem cell markers ALDH1 and CD44+/CD24- phenotype and their prognosis impact in invasive ductal carcinomaSemantic proximity Read ↗

Breast cancer stem cell markers CD44, CD24 and ALDH1: expression distribution within intrinsic molecular subtype.Semantic proximity Read ↗

An increase in cancer stem cell population after primary systemic therapy is a poor prognostic factor in breast cancer.Semantic proximity Read ↗

Aldehyde Dehydrogenase Activity of Breast Cancer Stem Cells Is Primarily Due To Isoform ALDH1A3 and Its Expression Is Predictive of MetastasisSemantic proximity Read ↗

ALDH1 as a Functional Marker of Cancer Stem and Progenitor CellsSemantic proximity Read ↗

Hypoxia promotes the phenotypic change of aldehyde dehydrogenase activity of breast cancer stem cellsSemantic proximity Read ↗

Distinct Expression Levels and Patterns of Stem Cell Marker, Aldehyde Dehydrogenase Isoform 1 (ALDH1), in Human Epithelial CancersSemantic proximity Read ↗

The Concept of Cancer Stem Cells: Elaborating on ALDH1B1 as an Emerging Marker of Cancer ProgressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.