Article
Huntington's disease alters human neurodevelopment.
Science (New York, N.Y.) - 14 Aug 2020
Barnat Monia, Capizzi Mariacristina, Aparicio Esther, Boluda Susana, Wennagel Doris, Kacher Radhia, Kassem Rayane, Lenoir Sophie, Agasse Fabienne, Braz Barbara Y, Liu Jeh-Ping, Ighil Julien, Tessier Aude, Zeitlin Scott O, Duyckaerts Charles, Dommergues Marc, Durr Alexandra, Humbert Sandrine
Abstract excerpt
Although Huntington's disease is a late-manifesting neurodegenerative disorder, both mouse studies and neuroimaging studies of presymptomatic mutation carriers suggest that Huntington's disease might affect neurodevelopment. To determine whether this is actually the case, we examined tissue from human fetuses (13 weeks gestation) that carried the Huntington's disease mutation. These tissues showed clear...
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