Article
Abnormal brain development in child and adolescent carriers of mutant huntingtin.
Neurology - 3 Sept 2019
van der Plas Ellen, Langbehn Douglas R, Conrad Amy L, Koscik Timothy R, Tereshchenko Alexander, Epping Eric A, Magnotta Vincent A, Nopoulos Peggy C
Abstract excerpt
OBJECTIVE: The huntingtin gene is critical for the formation and differentiation of the CNS, which raises questions about the neurodevelopmental effect of CAG expansion mutations within this gene (mHTT) that cause Huntington disease (HD). We sought to test the hypothesis that child and adolescent carriers of mHTT exhibit different brain growth compared to peers without the mutation by conducting structural MRI in...
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