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Article

Artificially stimulating retrotransposon activity increases mortality and accelerates a subset of aging phenotypes in Drosophila.

eLife - 18 Aug 2022

Rigal Joyce, Martin Anduaga Ane, Bitman Elena, Rivellese Emma, Kadener Sebastian, Marr Michael T

Abstract excerpt

Transposable elements (TEs) are mobile sequences of DNA that can become transcriptionally active as an animal ages. Whether TE activity is simply a by-product of heterochromatin breakdown or can contribute toward the aging process is not known. Here, we place the TE gypsy under the control of the UAS GAL4 system to model TE activation during aging. We find that increased TE activity shortens the life span of male...

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Identifiers

PMID: 35980024
DOI: 10.7554/eLife.80169
PMCID: PMC9427105

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