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Article

Epigenetic conflict on a degenerating Y chromosome increases mutational burden in Drosophila males.

Nature communications - 2 Nov 2020

Wei Kevin H-C, Gibilisco Lauren, Bachtrog Doris

Abstract excerpt

Large portions of eukaryotic genomes consist of transposable elements (TEs), and the establishment of transcription-repressing heterochromatin during early development safeguards genome integrity in Drosophila. Repeat-rich Y chromosomes can act as reservoirs for TEs ('toxic' Y effect), and incomplete epigenomic defenses during early development can lead to deleterious TE mobilization. Here, we contrast the...

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Identifiers

PMID: 33139741
DOI: 10.1038/s41467-020-19134-9
PMCID: PMC7608633

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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