Loss of hif-1 promotes resistance to the exogenous mitochondrial stressor ethidium bromide in Caenorhabditis elegans.

doi:10.1186/s12860-016-0112-x

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Article

Loss of hif-1 promotes resistance to the exogenous mitochondrial stressor ethidium bromide in Caenorhabditis elegans.

BMC cell biology - 13 Sept 2016

Kamal Muntasir, D'Amora Dayana R, Kubiseski Terrance J

Abstract excerpt

BACKGROUND: Mitochondrial dysfunction is one of the leading causes of neurological disorders in humans. Mitochondrial perturbations lead to adaptive mechanisms that include HIF-1 stabilization, though the consequences of increased levels of HIF-1 following mitochondrial stress remain poorly understood. RESULTS: Using Caenorhabditis elegans, we show that a hif-1 loss-of-function mutation confers resistance towards...

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Identifiers

PMID: 27618966
DOI: 10.1186/s12860-016-0112-x
PMCID: PMC5020483

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.