Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Glioma-induced inhibition of caspase-3 in microglia promotes a tumor-supportive phenotype.

Nature immunology - 1 Nov 2016

Shen Xianli, Burguillos Miguel A, Osman Ahmed M, Frijhoff Jeroen, Carrillo-Jiménez Alejandro, Kanatani Sachie, Augsten Martin, Saidi Dalel, Rodhe Johanna, Kavanagh Edel, Rongvaux Anthony, Rraklli Vilma, Nyman Ulrika, Holmberg Johan, Östman Arne, Flavell Richard A, Barragan Antonio, Venero Jose Luis, Blomgren Klas, Joseph Bertrand

Abstract excerpt

Glioma cells recruit and exploit microglia (the resident immune cells of the brain) for their proliferation and invasion ability. The underlying molecular mechanism used by glioma cells to transform microglia into a tumor-supporting phenotype has remained elusive. We found that glioma-induced microglia conversion was coupled to a reduction in the basal activity of microglial caspase-3 and increased...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caspase 3
Share to Gene Knockdown Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heterografts

Share to Microglia

Share to Mitochondrial Proteins

Share to Nitric Oxide Synthase Type II

Share to Thioredoxins

Share to Tumor Burden

Source

Identifiers

PMID: 27618552
DOI: 10.1038/ni.3545

Genes

NOS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Glioma-induced inhibition of caspase-3 in microglia promotes a tumor-supportive phenotype.PMID 27618552Read ↗

Microglia-glioma cross-talk: a two way approach to new strategies against glioma.Semantic proximity Read ↗

KCa3.1 inhibition switches the phenotype of glioma-infiltrating microglia/macrophages.Semantic proximity Read ↗

Galectin-3 depletion tames pro-tumoural microglia and restrains cancer cells growthSemantic proximity Read ↗

Toll-like receptor 2 mediates microglia/brain macrophage MT1-MMP expression and glioma expansionSemantic proximity Read ↗

Neuroprotective Effect of Fractalkine on Radiation-induced Brain Injury Through Promoting the M2 Polarization of Microglia.Semantic proximity Read ↗

Rat astrocytic tumour cells are associated with an anti-inflammatory microglial phenotype in an organotypic model.Semantic proximity Read ↗

Biological effects of selective COX-2 inhibitor NS398 on human glioblastoma cell linesSemantic proximity Read ↗

Prophylactic TLR9 stimulation reduces brain metastasis through microglia activationSemantic proximity Read ↗

Possible involvement of the M2 anti-inflammatory macrophage phenotype in growth of human gliomas.Semantic proximity Read ↗

Effects of ERK1/2 S-nitrosylation on ERK1/2 phosphorylation and cell survival in glioma cells.Semantic proximity Read ↗

Involvement of NOS2 Activity on Human Glioma Cell Growth, Clonogenic Potential, and Neurosphere GenerationSemantic proximity Read ↗

Regulation of the TLR4 pathway by the SENP3 gene in a model of hypoxia-induced inflammationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.