Article
KCa3.1 inhibition switches the phenotype of glioma-infiltrating microglia/macrophages.
Cell death & disease - 7 Apr 2016
Grimaldi A, D'Alessandro G, Golia M T, Grössinger E M, Di Angelantonio S, Ragozzino D, Santoro A, Esposito V, Wulff H, Catalano M, Limatola C
Abstract excerpt
Among the strategies adopted by glioma to successfully invade the brain parenchyma is turning the infiltrating microglia/macrophages (M/MΦ) into allies, by shifting them toward an anti-inflammatory, pro-tumor phenotype. Both glioma and infiltrating M/MΦ cells express the Ca(2+)-activated K(+) channel (KCa3.1), and the inhibition of KCa3.1 activity on glioma cells reduces tumor infiltration in the healthy brain...
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