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Article

Effects of ERK1/2 S-nitrosylation on ERK1/2 phosphorylation and cell survival in glioma cells.

International journal of molecular medicine - 1 Mar 2018

Jin Lei, Cao Yujia, Zhang Tong, Wang Peng, Ji Daofei, Liu Xuejiao, Shi Hengliang, Hua Lei, Yu Rutong, Gao Shangfeng

Abstract excerpt

Aberrant activation of extracellular signal‑regulated kinase 1/2 (ERK1/2) by phosphorylation modification can trigger tumor cell development in glioma. S‑nitrosylation, which refers to the covalent addition of a nitric oxide (NO) group to a cysteine (Cys) thiol, is an important post‑translational modification that occurs on numerous cancer‑associated proteins. Protein S‑nitrosylation can increase or decrease...

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Source

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Identifiers

PMID: 29286066
DOI: 10.3892/ijmm.2017.3334
PMCID: PMC5819938

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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