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Article

Biological effects of selective COX-2 inhibitor NS398 on human glioblastoma cell lines

13 May 2020

Abstract excerpt

BACKGROUND: Cyclooxygenase-2 (COX-2), an inflammation-associated enzyme, has been implicated in tumorigenesis and progression of glioblastoma (GBM). The poor survival of GBM was mainly associated with the presence of glioma stem cells (GSC) and the markedly inflammatory microenvironment. To further explore the involvement of COX-2 in glioma biology, the effects of NS398, a selective COX-2 inhibitor, were...

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PMID: 32435158
DOI: 10.1186/s12935-020-01250-7

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