Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Toll-like receptor 2 mediates microglia/brain macrophage MT1-MMP expression and glioma expansion

5 Sept 2013

Abstract excerpt

BACKGROUND: Glioblastomas are the most aggressive primary brain tumors in humans. Microglia/brain macrophage accumulation in and around the tumor correlates with malignancy and poor clinical prognosis of these tumors. We have previously shown that microglia promote glioma expansion through upregulation of membrane type 1 matrix metalloprotease (MT1-MMP). This upregulation depends on signaling via the Toll-like...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Glioma Diagnosis and Treatment
Share to Immune Response and Inflammation
Share to Neuroinflammation and Neurodegeneration Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24014382
DOI: 10.1093/neuonc/not115

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Toll-like receptor 2 mediates microglia/brain macrophage MT1-MMP expression and glioma expansionPMID 24014382Read ↗

Macrophages/Microglia in the Glioblastoma Tumor MicroenvironmentSemantic proximity Read ↗

In Search for Reliable Markers of Glioma-Induced Polarization of MicrogliaSemantic proximity Read ↗

Glioma-Associated Microglia/Macrophages Display an Expression Profile Different from M1 and M2 Polarization and Highly Express Gpnmb and Spp1Semantic proximity Read ↗

Microglia-glioma cross-talk: a two way approach to new strategies against glioma.Semantic proximity Read ↗

Pro-inflammatory and proliferative microglia drive progression of glioblastoma.Semantic proximity Read ↗

Distinct roles of CSF family cytokines in macrophage infiltration and activation in glioma progression and injury response.Semantic proximity Read ↗

GBM-Derived Wnt3a Induces M2-Like Phenotype in Microglial Cells Through Wnt/β-Catenin Signaling.Semantic proximity Read ↗

Molecular profiling of the tumor microenvironment in glioblastoma patients: correlation of microglia/macrophage polarization state with metalloprotease expression profiles and survivalSemantic proximity Read ↗

Microglia promote colonization of brain tissue by breast cancer cells in a Wnt‐dependent waySemantic proximity Read ↗

Down-regulation of Aquaporin-1 mediates a microglial phenotype switch affecting glioma growth.Semantic proximity Read ↗

Proinflammatory-activated glioma cells induce a switch in microglial polarization and activation status, from a predominant M2b phenotype to a mixture of M1 and M2a/B polarized cells.Semantic proximity Read ↗

Possible involvement of the M2 anti-inflammatory macrophage phenotype in growth of human gliomas.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.