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Article

Rat astrocytic tumour cells are associated with an anti-inflammatory microglial phenotype in an organotypic model.

Neuropathology and applied neurobiology - 1 Apr 2013

Billingham C, Powell M R, Jenner K A, Johnston D A, Gatherer M, Nicoll J A R, Boche D

Abstract excerpt

AIM: Microglia form a high proportion of cells in glial tumours but their role in supporting or inhibiting tumour growth is unclear. Here we describe the establishment of an in vitro model to investigate their role in astrocytomas. METHODS: Rat hippocampal slices were prepared and, after 7 days to allow microglia to become quiescent, rat C6 astrocytic tumour cells were added. Over the following 7 days,...

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PMID: 22631872
DOI: 10.1111/j.1365-2990.2012.01283.x

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