Article
Involvement of Na/K-ATPase in hydrogen peroxide-induced activation of the Src/ERK pathway in LLC-PK1 cells.
Free radical biology & medicine - 1 Jun 2014
Wang Yu, Ye Qiqi, Liu Changxuan, Xie Jeffrey X, Yan Yanling, Lai Fangfang, Duan Qiming, Li Xiaomei, Tian Jiang, Xie Zijian
Abstract excerpt
We have shown that Na/K-ATPase interacts with Src. Here, we test the role of this interaction in H2O2-induced activation of Src and ERK. We found that exposure of LLC-PK1 cells to H2O2 generated by the addition of glucose oxidase into the culture medium activated Src and ERK1/2. It also caused a modest reduction in the number of surface Na/K-ATPases and in ouabain-sensitive Rb(+) uptake. These effects of H2O2...
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