Article
Cys palmitoylation of the beta subunit modulates gating of the epithelial sodium channel.
The Journal of biological chemistry - 1 Oct 2010
Mueller Gunhild M, Maarouf Ahmad B, Kinlough Carol L, Sheng Nan, Kashlan Ossama B, Okumura Sora, Luthy Sarah, Kleyman Thomas R, Hughey Rebecca P
Abstract excerpt
The epithelial Na(+) channel (ENaC) is comprised of three homologous subunits (α, β, and γ) that have a similar topology with two transmembrane domains, a large extracellular region, and cytoplasmic N and C termini. Although ENaC activity is regulated by a number of factors, palmitoylation of its cytoplasmic Cys residues has not been previously described. Fatty acid-exchange chemistry was used to determine...
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