Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

cGMP-dependent protein kinase 1 polymorphisms underlie renal sodium handling impairment.

Hypertension (Dallas, Tex. : 1979) - 1 Dec 2013

Citterio Lorena, Ferrandi Mara, Delli Carpini Simona, Simonini Marco, Kuznetsova Tatiana, Molinari Isabella, Dell' Antonio Giacomo, Lanzani Chiara, Merlino Lino, Brioni Elena, Staessen Jan A, Bianchi Giuseppe, Manunta Paolo

Abstract excerpt

Defective pressure-natriuresis related to abnormalities in the natriuretic response has been associated with hypertension development. A major signaling pathway mediating pressure natriuresis involves the cGMP-dependent protein kinase 1 (PRKG1) that, once activated by Src kinase, inhibits renal Na(+) reabsorption via a direct action on basolateral Na-K ATPase and luminal Na-H exchanger type 3, as shown in renal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Alleles

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Blood Pressure

Share to Hypertension

Share to Kidney

Share to Polymorphism, Genetic

Share to Sodium

Share to Sodium, Dietary

Source

Identifiers

PMID: 24060892
DOI: 10.1161/HYPERTENSIONAHA.113.01628

Genes

PRKG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

cGMP-dependent protein kinase 1 polymorphisms underlie renal sodium handling impairment.PMID 24060892Read ↗

Genes involved in vasoconstriction and vasodilation system affect salt-sensitive hypertension.Semantic proximity Read ↗

Genetic variants of cGMP-dependent protein kinase genes and salt sensitivity of blood pressure: the GenSalt study.Semantic proximity Read ↗

Kidney ion handling genes and their interaction in blood pressure controlSemantic proximity Read ↗

The importance of G protein-coupled receptor kinase 4 (GRK4) in pathogenesis of salt sensitivity, salt sensitive hypertension and response to antihypertensive treatment.Semantic proximity Read ↗

Role of the Cation-chloride-cotransporters in Cardiovascular DiseaseSemantic proximity Read ↗

Polymorphisms in the serum- and glucocorticoid-inducible kinase 1 gene are associated with blood pressure and renin response to dietary salt intake.Semantic proximity Read ↗

A gene-based analysis of variants in the serum/glucocorticoid regulated kinase (SGK) genes with blood pressure responses to sodium intake: the GenSalt Study.Semantic proximity Read ↗

Sodium and kidney disease.Semantic proximity Read ↗

CACNA1D Gene Polymorphisms Associate With Increased Blood Pressure and Salt Sensitivity of Blood Pressure in White Individuals.Semantic proximity Read ↗

Low prevalence of nonconservative mutations of serum and glucocorticoid-regulated kinase (SGK1) gene in hypertensive and renal patients.Semantic proximity Read ↗

A CLCNKA polymorphism (rs10927887; p.Arg83Gly) previously linked to heart failure is associated with the estimated glomerular filtration rate in the RENASTUR cohort.Semantic proximity Read ↗

Cellular mediators of renal vascular dysfunction in hypertension.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.