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Article

A depression-like phenotype is associated with discrete defects in the primary hippocampal circuit.

Translational psychiatry - 16 May 2026

Gunn Benjamin G, Yang Chenyi C, Lauterborn Julie C, Pruess Benedict S, Quintanilla Julian, Ge Katelyn, Gall Christine M, Lynch Gary

Abstract excerpt

Major depressive disorder is known to disturb the hippocampus, but how this impacts signal processing performed by the structure remains poorly understood. Here, we report that single housing (7-10 days) promotes a depression-like phenotype in young adult mice that is associated with a robust, yet surprisingly discreet defect in information flow across the primary hippocampal circuit. In addition to sociability...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42143033
DOI: 10.1038/s41398-026-04094-3
PMCID: PMC13346759

Genes

CA1
CA3
LPP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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