Article

Altered Hippocampal-Prefrontal Neural Dynamics in Mouse Models of Down Syndrome

2019-05-23

Abstract excerpt

<h4>Summary</h4> Altered neural dynamics in medial prefrontal cortex (mPFC) and hippocampus may contribute to cognitive impairments in the complex chromosomal disorder, Down Syndrome (DS). Here, we demonstrate non-overlapping behavioural differences associated with distinct abnormalities in hippocampal and mPFC electrophysiology during a canonical spatial memory task in three partially trisomic mouse models of DS...

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Literature Corpus work: 16ce5a7f-ce40-5c2f-8e50-0b55ad1c897a
DOI: 10.1101/644849

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