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Article

Alterations and molecular targeting of the GSK-3 regulator, PI3K, in head and neck cancer.

Biochimica et biophysica acta. Molecular cell research - 1 Jun 2020

Lee Michelle J, Jin Nan, Grandis Jennifer R, Johnson Daniel E

Abstract excerpt

Head and neck squamous cell carcinoma (HNSCC) is a highly morbid, genetically unstable disease derived from the mucoepithelium of the upper aerodigestive tract. Recent characterization of this disease has implicated the PI3K-Akt-mTOR pathway as one of the most frequently dysregulated pathways. As such, there are several classes of PI3K inhibitors currently undergoing clinical trials. In this article, we review...

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Identifiers

PMID: 32061630
DOI: 10.1016/j.bbamcr.2020.118679
PMCID: PMC7671657

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