Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

GSK‐3 in Neurodegenerative Diseases

1 Jan 2011

Abstract excerpt

Glycogen synthase kinase-3 (GSK-3) regulates multiple cellular processes, and its dysregulation is implicated in the pathogenesis of diverse diseases. In this paper we will focus on the dysfunction of GSK-3 in Alzheimer's disease and Parkinson's disease. Specifically, GSK-3 is known to interact with tau, β-amyloid (Aβ), and α-synuclein, and as such may be crucially involved in both diseases. Aβ production, for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Parkinson's Disease Mechanisms and Treatments
Share to Wnt/β-catenin signaling in development and cancer

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21629738
DOI: 10.4061/2011/189246

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

GSK‐3 in Neurodegenerative DiseasesPMID 21629738Read ↗

Mechanisms and Therapeutic Implications of GSK-3 in Treating NeurodegenerationSemantic proximity Read ↗

GSK-3Î², a pivotal kinase in Alzheimer diseaseSemantic proximity Read ↗

The role of GSK3 in Alzheimer diseaseSemantic proximity Read ↗

GSK-3β Contributes to Parkinsonian Dopaminergic Neuron Death: Evidence From Conditional Knockout Mice and TideglusibSemantic proximity Read ↗

Functional Implications of Glycogen Synthase Kinase‐3‐Mediated Tau PhosphorylationSemantic proximity Read ↗

Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration <i>in vivo</i>Semantic proximity Read ↗

Decreased glycogen synthase kinase-3 levels and activity contribute to Huntington's disease.Semantic proximity Read ↗

GSK-3β inhibitors can rescue neurons through the prosurvival(autophagy) mechanism in Parkinson’s DiseaseSemantic proximity Read ↗

Selectively Silencing GSK-3 Isoforms Reduces Plaques and Tangles in Mouse Models of Alzheimer's DiseaseSemantic proximity Read ↗

Effects of mutations in Wnt/β-catenin, hedgehog, Notch and PI3K pathways on GSK-3 activity-Diverse effects on cell growth, metabolism and cancer.Semantic proximity Read ↗

Recent advances in understanding the cellular roles of GSK-3Semantic proximity Read ↗

Inhibition of GSK-3 Ameliorates Aβ Pathology in an Adult-Onset Drosophila Model of Alzheimer's DiseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.