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Article

Programmed death-1 controls T cell survival by regulating oxidative metabolism.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 2015

Tkachev Victor, Goodell Stefanie, Opipari Anthony W, Hao Ling-Yang, Franchi Luigi, Glick Gary D, Ferrara James L M, Byersdorfer Craig A

Abstract excerpt

The coinhibitory receptor programmed death-1 (PD-1) maintains immune homeostasis by negatively regulating T cell function and survival. Blockade of PD-1 increases the severity of graft-versus-host disease (GVHD), but the interplay between PD-1 inhibition and T cell metabolism is not well studied. We found that both murine and human alloreactive T cells concomitantly upregulated PD-1 expression and increased...

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Identifiers

PMID: 25972478
DOI: 10.4049/jimmunol.1402180
PMCID: PMC4562423

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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