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Article

Activating mutations in protein tyrosine phosphatase Ptpn11 (Shp2) enhance reactive oxygen species production that contributes to myeloproliferative disorder.

PloS one - 1 Jan 2013

Xu Dan, Zheng Hong, Yu Wen-Mei, Qu Cheng-Kui

Abstract excerpt

Gain of function (GOF) mutations in protein tyrosine phosphatase Ptpn11 have been identified in childhood leukemias, and these mutations are sufficient to drive the development of myeloproliferative disorder and malignant leukemias in mice. However, the molecular mechanisms by which Ptpn11 mutations induce these malignancies are not completely understood. Here we report that Ptpn11 GOF mutations cause cytokine...

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Identifiers

PMID: 23675459
DOI: 10.1371/journal.pone.0063152
PMCID: PMC3651249

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