Article
Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression.
Nature - 31 Jul 2003
Neumann Carola A, Krause Daniela S, Carman Christopher V, Das Shampa, Dubey Devendra P, Abraham Jennifer L, Bronson Roderick T, Fujiwara Yuko, Orkin Stuart H, Van Etten Richard A
Abstract excerpt
Reactive oxygen species are involved in many cellular metabolic and signalling processes and are thought to have a role in disease, particularly in carcinogenesis and ageing. We have generated mice with targeted inactivation of Prdx1, a member of the peroxiredoxin family of antioxidant enzymes. Here we show that mice lacking Prdx1 are viable and fertile but have a shortened lifespan owing to the development...
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