Increased Circulating Levels of Interleukin‐6 Induce Perturbation in Redox‐Regulated Signaling Cascades in Muscle of Dystrophic Mice

Abstract excerpt

Duchenne muscular dystrophy (DMD) is an X-linked genetic disease in which dystrophin gene is mutated, resulting in dysfunctional or absent dystrophin protein. The pathology of dystrophic muscle includes degeneration, necrosis with inflammatory cell invasion, regeneration, and fibrous and fatty changes. Nevertheless, the mechanisms by which the absence of dystrophin leads to muscle degeneration remain to be fully...

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