Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Response to Oxidative Damage Correlates with Driver Mutations and Clinical Outcome in Patients with Myelofibrosis

5 Jan 2022

Abstract excerpt

Myelofibrosis (MF) is the Philadelphia-negative myeloproliferative neoplasm characterized by the worst prognosis and no response to conventional therapy. Driver mutations in JAK2 and CALR impact on JAK-STAT pathway activation but also on the production of reactive oxygen species (ROS). ROS play a pivotal role in inflammation-induced oxidative damage to cellular components including DNA, therefore leading to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chronic Myeloid Leukemia Treatments
Share to Kruppel-like factors research
Share to Myeloproliferative Neoplasms: Diagnosis and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35052617
DOI: 10.3390/antiox11010113

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Response to Oxidative Damage Correlates with Driver Mutations and Clinical Outcome in Patients with MyelofibrosisPMID 35052617Read ↗

Crosstalk between Oxidative Stress, Chronic Inflammation and Disease Progression in Essential ThrombocythemiaSemantic proximity Read ↗

Oxidative Stress Levels, JAK2V617F Mutational Status and Thrombotic Complications in Patients with Essential ThrombocythemiaSemantic proximity Read ↗

Oxidative Stress in Fanconi Anemia Hematopoiesis and Disease ProgressionSemantic proximity Read ↗

The Role of Reactive Oxygen Species in Acute Myeloid LeukaemiaSemantic proximity Read ↗

Oxidative Stress, Bone Marrow Failure, and Genome Instability in Hematopoietic Stem CellsSemantic proximity Read ↗

Synergic Crosstalk between Inflammation, Oxidative Stress, and Genomic Alterations in BCR–ABL-Negative Myeloproliferative NeoplasmSemantic proximity Read ↗

JAK2V617F mediates resistance to DNA damage-induced apoptosis by modulating FOXO3A localization and Bcl-xL deamidation.Semantic proximity Read ↗

Whole Blood Transcriptional Profiling Reveals Deregulation of Oxidative and Antioxidative Defence Genes in Myelofibrosis and Related Neoplasms. Potential Implications of Downregulation of Nrf2 for Genomic Instability and Disease ProgressionSemantic proximity Read ↗

Elevated levels of oxidized nucleosides in individuals with the JAK2V617F mutation from a general population study.Semantic proximity Read ↗

Effect of 5-Azacitine Treatment on Redox Status and Inflammatory Condition in MDS PatientsSemantic proximity Read ↗

A role for reactive oxygen species in JAK2V617F myeloproliferative neoplasm progressionSemantic proximity Read ↗

Oxidative stress is increased in primary and post-polycythemia vera myelofibrosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.