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Article

KRIT1 Regulates the Homeostasis of Intracellular Reactive Oxygen Species

26 Jul 2010

Abstract excerpt

KRIT1 is a gene responsible for Cerebral Cavernous Malformations (CCM), a major cerebrovascular disease characterized by abnormally enlarged and leaky capillaries that predispose to seizures, focal neurological deficits, and fatal intracerebral hemorrhage. Comprehensive analysis of the KRIT1 gene in CCM patients has suggested that KRIT1 functions need to be severely impaired for pathogenesis. However, the...

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Share to Intracerebral and Subarachnoid Hemorrhage Research
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PMID: 20668652
DOI: 10.1371/journal.pone.0011786

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