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Article

Molecular determinants of transport stimulation of EAAT2 are located at interface between the trimerization and substrate transport domains.

Journal of neurochemistry - 1 Apr 2015

Mortensen Ole V, Liberato José L, Coutinho-Netto Joaquim, Dos Santos Wagner F, Fontana Andréia C K

Abstract excerpt

Excitatory amino acid transporters (EAATs) regulate glutamatergic signal transmission by clearing extracellular glutamate. Dysfunction of these transporters has been implicated in the pathogenesis of various neurological disorders. Previous studies have shown that venom from the spider Parawixia bistriata and a purified compound (Parawixin1) stimulate EAAT2 activity and protect retinal tissue from ischemic...

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Identifiers

PMID: 25626691
DOI: 10.1111/jnc.13047

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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