Functional Roles of the Edited Isoform of GluA2 in GluA2-Containing AMPA Receptor Channels.

doi:10.1021/acs.biochem.6b01041

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Article

Functional Roles of the Edited Isoform of GluA2 in GluA2-Containing AMPA Receptor Channels.

Biochemistry - 21 Mar 2017

Han Yan, Lin Chi-Yen, Niu Li

Abstract excerpt

GluA2R is the edited isoform at the Q/R site of the AMPA receptor GluA2 subunit. In vivo, GluA2R assembles with other AMPA receptor subunits into a high-conductance, tetrameric complex. Here we study the functional role of GluA2R in the context of GluA1/2R and GluA2Q/2R heteromeric receptors, usi...

Topics

Amino Acid Substitution
Animals
Gene Expression
Glutamic Acid
HEK293 Cells
Humans
Ion Channel Gating
Kinetics
Mutation
Patch-Clamp Techniques
Photolysis
Protein Isoforms
Protein Multimerization
Protein Subunits
Rats
Receptors, AMPA
Recombinant Proteins

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