Article
An evolutionary analysis of RAC2 identifies haplotypes associated with human autoimmune diseases.
Molecular biology and evolution - 1 Dec 2011
Sironi Manuela, Guerini Franca Rosa, Agliardi Cristina, Biasin Mara, Cagliani Rachele, Fumagalli Matteo, Caputo Domenico, Cassinotti Andrea, Ardizzone Sandro, Zanzottera Milena, Bolognesi Elisabetta, Riva Stefania, Kanari Yasuyoshi, Miyazawa Masaaki, Clerici Mario
Abstract excerpt
The human RAC2 gene encodes a small GTP-binding protein with a pivotal role in immune activation and in the induction of peripheral immune tolerance through restimulation-induced cell death (RICD). Different human pathogens target the protein product of RAC2, suggesting that the gene may be subject to natural selection, and that variants in RAC2 may affect immunological phenotypes in humans. We scanned the...
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