Genome-Wide Association Analysis Reveals Suggestive Genetic Loci for Thiopurine-Induced Pancreatitis in inflammatory bowel disease patients

Abstract excerpt

<title>Abstract</title> <p>Abstract Inflammatory bowel disease (IBD) requires the use of immunosuppressive therapies. Thiopurines (azathioprine and 6-mercaptopurine) are among the therapeutic options. However, adverse drug reactions (ADRs) affect 25% of patients, causing treatment discontinuation in 17% of cases. Thiopurine-induced pancreatitis, defined by meeting ≥2 criteria of amylase/lipase >3× upper reference...

Topics

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• Azathioprine
• HLA-DQ alpha-Chains
• HLA-DRB1 Chains
• Immunosuppressive Agents
• Inflammatory Bowel Diseases
• Mercaptopurine
• Molecular Structure
• Pancreatitis

Identifiers and source

Literature Corpus work

254909ee-6c8a-56f0-8143-2b189e45ca3a

DOI

10.21203/rs.3.rs-9246014/v1