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Article

TRiC subunits enhance BDNF axonal transport and rescue striatal atrophy in Huntington's disease.

Proceedings of the National Academy of Sciences of the United States of America - 20 Sept 2016

Zhao Xiaobei, Chen Xu-Qiao, Han Eugene, Hu Yue, Paik Paul, Ding Zhiyong, Overman Julia, Lau Alice L, Shahmoradian Sarah H, Chiu Wah, Thompson Leslie M, Wu Chengbiao, Mobley William C

Abstract excerpt

Corticostriatal atrophy is a cardinal manifestation of Huntington's disease (HD). However, the mechanism(s) by which mutant huntingtin (mHTT) protein contributes to the degeneration of the corticostriatal circuit is not well understood. We recreated the corticostriatal circuit in microfluidic chambers, pairing cortical and striatal neurons from the BACHD model of HD and its WT control. There were reduced synaptic...

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Share to Atrophy
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptor, trkB

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Source

Open in PubMed Open full text

Identifiers

PMID: 27601642
DOI: 10.1073/pnas.1603020113
PMCID: PMC5035849

Genes

BDNF
CCT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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