Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transneuronal propagation of mutant huntingtin contributes to non-cell autonomous pathology in neurons.

Nature neuroscience - 1 Aug 2014

Pecho-Vrieseling Eline, Rieker Claus, Fuchs Sascha, Bleckmann Dorothee, Esposito Maria Soledad, Botta Paolo, Goldstein Chris, Bernhard Mario, Galimberti Ivan, Müller Matthias, Lüthi Andreas, Arber Silvia, Bouwmeester Tewis, van der Putten Herman, Di Giorgio Francesco Paolo

Abstract excerpt

In Huntington's disease (HD), whether transneuronal spreading of mutant huntingtin (mHTT) occurs and its contribution to non-cell autonomous damage in brain networks is largely unknown. We found mHTT spreading in three different neural network models: human neurons integrated in the neural network of organotypic brain slices of HD mouse model, an ex vivo corticostriatal slice model and the corticostriatal pathway...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Coculture Techniques
Share to Embryonic Stem Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Huntingtin Protein

Share to Huntington Disease

Share to Mice, Inbred CBA

Share to Nerve Net

Share to Nerve Tissue Proteins

Share to Neurons

Source

Identifiers

PMID: 25017010
DOI: 10.1038/nn.3761

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transneuronal propagation of mutant huntingtin contributes to non-cell autonomous pathology in neurons.PMID 25017010Read ↗

Synaptic pathology in Huntington's disease: Beyond the corticostriatal pathwaySemantic proximity Read ↗

The Prion-Like Spreading of Alpha-Synuclein in Parkinson’s Disease: Update on Models and HypothesesSemantic proximity Read ↗

<i>In vivo</i> progressive degeneration of Huntington’s disease patient-derived neurons reveals human-specific pathological phenotypesSemantic proximity Read ↗

Unconventional Secretion and Intercellular Transfer of Mutant HuntingtinSemantic proximity Read ↗

Propagation of pathology through brain networks in neurodegenerative diseases: from molecules to clinical phenotypes.Semantic proximity Read ↗

Prion-like propagation of mutant SOD1 misfolding and motor neuron disease spread along neuroanatomical pathwaysSemantic proximity Read ↗

Pathological cell-cell interactions are necessary for striatal pathogenesis in a conditional mouse model of Huntington's diseaseSemantic proximity Read ↗

Huntington's Disease and the Striatal Medium Spiny Neuron: Cell-Autonomous and Non-Cell-Autonomous Mechanisms of DiseaseSemantic proximity Read ↗

Cell-Autonomous and Non-cell-Autonomous Pathogenic Mechanisms in Huntington's Disease: Insights from In Vitro and In Vivo ModelsSemantic proximity Read ↗

Templated misfolding of Tau by prion-like seeding along neuronal connections impairs neuronal network function and associated behavioral outcomes in Tau transgenic mice.Semantic proximity Read ↗

The roles of connectivity and neuronal phenotype in determining the pattern of α-synuclein pathology in Parkinson's disease.Semantic proximity Read ↗

Differential changes to D1 and D2 medium spiny neurons in the 12-month-old Q175+/- mouse model of Huntington’s DiseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.