Article
TRiC's tricks inhibit huntingtin aggregation.
eLife - 9 Jul 2013
Shahmoradian Sarah H, Galaz-Montoya Jesus G, Schmid Michael F, Cong Yao, Ma Boxue, Spiess Christoph, Frydman Judith, Ludtke Steven J, Chiu Wah
Abstract excerpt
In Huntington's disease, a mutated version of the huntingtin protein leads to cell death. Mutant huntingtin is known to aggregate, a process that can be inhibited by the eukaryotic chaperonin TRiC (TCP1-ring complex) in vitro and in vivo. A structural understanding of the genesis of aggregates and their modulation by cellular chaperones could facilitate the development of therapies but has been hindered by the...
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