Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Controlling secretion to limit chemoresistance.

Genes & development - 15 Aug 2016

Georgilis Athena, Gil Jesús

Abstract excerpt

The tumor microenvironment influences cancer progression and therapy outcome by mechanisms not yet fully understood. In this issue of Genes & Development, Bent and colleagues (pp. 1811-1821) show how chemotherapy causes endothelial senescence. Interestingly, senescent endothelial cells do not mount a typical senescence-associated secretory phenotype but instead acutely secrete IL-6, promoting chemoresistance....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cellular Senescence
Share to Drug Resistance, Neoplasm
Share to Interleukin-6

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phenotype

Share to Phosphatidylinositol 3-Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 27601527
DOI: 10.1101/gad.288571.116
PMCID: PMC5024677

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Controlling secretion to limit chemoresistance.PMID 27601527Read ↗

Harnessing the interaction between redox signaling and senescence to restrain tumor drug resistanceSemantic proximity Read ↗

Overcoming the senescence-associated secretory phenotype (SASP): a complex mechanism of resistance in the treatment of cancer.Semantic proximity Read ↗

Targeting senescence‐associated secretory phenotypes to remodel the tumour microenvironment and modulate tumour outcomesSemantic proximity Read ↗

Senescence and the tumor-immune landscape: Implications for cancer immunotherapy.Semantic proximity Read ↗

A Transient Pseudosenescent Secretome Promotes Tumor Growth after Antiangiogenic Therapy Withdrawal.Semantic proximity Read ↗

Senescent stromal cells promote cancer resistance through SIRT1 loss-potentiated overproduction of small extracellular vesiclesSemantic proximity Read ↗

SASP: Tumor Suppressor or Promoter? Yes!Semantic proximity Read ↗

Targeting epiregulin in the treatment-damaged tumor microenvironment restrains therapeutic resistanceSemantic proximity Read ↗

Autophagy inhibition signals through senescence to promote tumor suppressionSemantic proximity Read ↗

MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation.Semantic proximity Read ↗

Cellular senescence and metabolic reprogramming: Unraveling the intricate crosstalk in the immunosuppressive tumor microenvironmentSemantic proximity Read ↗

Oncogene inactivation-induced senescence facilitates tumor relapseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.