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Article

SASP: Tumor Suppressor or Promoter? Yes!

Trends in cancer - 1 Nov 2016

Rao Sonia G, Jackson James G

Abstract excerpt

Cellular senescence is a permanent growth arrest in cells with damage or stress that could lead to transformation. Some tumor cells also undergo senescence in response to chemotherapy. Senescent cells secrete cytokines and other factors of the senescence-associated secretory phenotype (SASP) that contribute to tumor suppression by enforcing arrest and recruiting immune cells that remove these damaged or...

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Identifiers

PMID: 28741506
DOI: 10.1016/j.trecan.2016.10.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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