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Article

Mutually orthogonal pyrrolysyl-tRNA synthetase/tRNA pairs.

Nature chemistry - 1 Aug 2018

Willis Julian C W, Chin Jason W

Abstract excerpt

Genetically encoding distinct non-canonical amino acids (ncAAs) into proteins synthesized in cells requires mutually orthogonal aminoacyl-tRNA synthetase (aaRS)/tRNA pairs. The pyrrolysyl-tRNA synthetase/PyltRNA pair from Methanosarcina mazei (Mm) has been engineered to incorporate diverse ncAAs and is commonly considered an ideal pair for genetic code expansion. However, finding new aaRS/tRNA pairs that share...

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Identifiers

PMID: 29807989
DOI: 10.1038/s41557-018-0052-5
PMCID: PMC6055992

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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