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Article

Nicotine exposure and metabolizer phenotypes from analysis of urinary nicotine and its 15 metabolites by LC-MS.

Bioanalysis - 1 Apr 2011

Rangiah Kannan, Hwang Wei-Ting, Mesaros Clementina, Vachani Anil, Blair Ian A

Abstract excerpt

UNLABELLED: Smokers who inhale less deeply are exposed to lower amounts of the toxic substances present in tobacco smoke. In order to more rigorously assess tobacco smoke exposure, it is necessary to have an accurate method for quantifying nicotine and all of its known metabolites. METHODS: A stable-isotope dilution LC-MRM/MS assay has been developed for quantification of urinary nicotine and the 15 possible...

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Identifiers

PMID: 21452992
DOI: 10.4155/bio.11.42
PMCID: PMC3134267

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Source receipt: pubmed, retrieved 7 Sept 2026.

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