Article
Requirements of transcription factor Smad-dependent and -independent TGF-β signaling to control discrete T-cell functions.
Proceedings of the National Academy of Sciences of the United States of America - 17 Jan 2012
Gu Ai-Di, Wang Yunqi, Lin Lin, Zhang Song S, Wan Yisong Y
Abstract excerpt
TGF-β modulates immune response by suppressing non-regulatory T (Treg) function and promoting Treg function. The question of whether TGF-β achieves distinct effects on non-Treg and Treg cells through discrete signaling pathways remains outstanding. In this study, we investigated the requirements of Smad-dependent and -independent TGF-β signaling for T-cell function. Smad2 and Smad3 double deficiency in T cells...
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