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Article

Signal transduction in CD4+CD25+ regulatory T cells: CD25 and IL-2.

Frontiers in bioscience : a journal and virtual library - 1 Jan 2006

Thornton Angela M

Abstract excerpt

IL-2 was originally identified as a growth factor critical for T cell proliferation in vitro. Although the early studies of IL-2 strongly implied an obligate role of IL-2 in T cell growth, it was later shown that mice deficient in IL-2 or in IL-2R developed an unexpected lymphocytic hyperproliferation and subsequent autoimmune disease. In separate studies of autoimmunity, it was observed that a population of CD4+...

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Source

Identifiers

PMID: 16146782
DOI: 10.2741/1848

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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