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Article

Enhanced immunogenicity of the Brucella A19 ΔbtpB mutant leads to accelerated clearance in the host.

Frontiers in immunology - 1 Jan 2026

Yuan Ye, Bu Xuan, Zhai Yunyi, WuDong Gaowa, Lu Qing, Tang Ting, Zhou Dong, Liu Wei, Jin Yaping, Wang Aihua

Abstract excerpt

Introduction: Brucella is a Gram-negative facultative intracellular bacterium that can cause fever, abortion, and other symptoms in humans and various mammals. btpB, a type IV secretion system (T4SS) effector of Brucella, plays a critical role in regulating Brucella infection and inhibiting the host's innate immune response. Methods: In this study, a btpB mutant strain of Brucella A19 (ΔbtpB) was constructed...

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Identifiers

PMID: 41694393
DOI: 10.3389/fimmu.2026.1747903
PMCID: PMC12901473

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