Article
Attenuated signature-tagged mutagenesis mutants of Brucella melitensis identified during the acute phase of infection in mice.
Infection and immunity - 1 Dec 2003
Lestrate P, Dricot A, Delrue R-M, Lambert C, Martinelli V, De Bolle X, Letesson J-J, Tibor A
Abstract excerpt
For this study, we screened 1,152 signature-tagged mutagenesis mutants of Brucella melitensis 16M in a mouse model of infection and found 36 of them to be attenuated in vivo. Molecular characterization of transposon insertion sites showed that for four mutants, the affected genes were only present in Rhizobiaceae. Another mutant contained a disruption in a gene homologous to mosA, which is involved in rhizopine...
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