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Persistent articular infection and host reactive response contribute to <i>Brucella</i> -induced spondyloarthritis in SKG mice

2025-02-21

Abstract excerpt

Brucellosis, one of the most prevalent zoonotic diseases worldwide, often results in osteoarticular complications including large joint and axial arthritis mimicking spondyloarthritis. To model this chronic manifestation, we infected autoimmunity-prone SKG mice containing a mutation in the T-cell adaptor ZAP-70 with Brucella species. B. melitensis infection resulted in a fully penetrant, readily scoreable diseas...

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Literature Corpus work
93ee23d8-848e-5cd6-a5f3-12f9464495fe
DOI
10.1101/2025.02.18.638825
Open publication

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Persistent articular infection and host reactive response contribute to <i>Brucella</i> -induced spondyloarthritis in SKG miceDOI 10.1101/2025.02.18.638825
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