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Article

Carboxypeptidase N-deficient mice present with polymorphic disease phenotypes on induction of experimental autoimmune encephalomyelitis.

Immunobiology - 1 Feb 2014

Hu Xianzhen, Wetsel Rick A, Ramos Theresa N, Mueller-Ortiz Stacey L, Schoeb Trenton R, Barnum Scott R

Abstract excerpt

Carboxypeptidase N (CPN) is a member of the carboxypeptidase family of enzymes that cleave carboxy-terminal lysine and arginine residues from a large number of biologically active peptides and proteins. These enzymes are best known for their roles in modulating the activity of kinins, complement anaphylatoxins and coagulation proteins. Although CPN makes important contributions to acute inflammatory events,...

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Identifiers

PMID: 24028840
DOI: 10.1016/j.imbio.2013.08.007
PMCID: PMC4339068

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