Article
Bone marrow-derived mast cells accumulate in the central nervous system during inflammation but are dispensable for experimental autoimmune encephalomyelitis pathogenesis.
Journal of immunology (Baltimore, Md. : 1950) - 1 May 2009
Bennett Jami L, Blanchet Marie-Renée, Zhao Linlin, Zbytnuik Lori, Antignano Frann, Gold Matthew, Kubes Paul, McNagny Kelly M
Abstract excerpt
Reports showing that W/W(v) mice are protected from experimental autoimmune encephalomyelitis (EAE, a murine model of multiple sclerosis), have implicated mast cells as an essential component in disease susceptibility, but the role of mast cell trafficking has not been addressed. In this study, we have used both mast cell transplantation and genetic mutations (Cd34(-/-), W/W(v), W(sh)/W(sh)) to investigate the...
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